In the two years following the death of Elizabeth Keen, Raymond Reddington (James Spader) and the members of the FBI Task Force have disbanded — their lives now changed in unexpected ways and with Reddington's whereabouts unknown. Finding themselves each at a crossroads, a common purpose compels them to renew their original mission: to take down dangerous, vicious and eccentric Blacklisters. In the process, they begin to uncover lethal adversaries, unimaginable conspiracies and surprising betrayals that will threaten alliances and spur vengeance for the past, led by the most devious criminal of them all: Raymond Reddington.